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J Cell Biol 4 January ; 1 : 13— Although many alterations are caused by mutations in splicing als or regulatory sequence elements, recent studies have noted the disruptive impact of mutated generic spliceosome components and splicing regulatory proteins. This review highlights recent progress in our understanding of how the altered splicing function of RNA-binding proteins contributes to myelodysplastic syndromes, cancer, and neuropathologies. Nearly all protein-encoding human genes have multiple exons that are combined in alternative ways to Latina escorts in Abbotsford distinct mRNAs, Sherbrooke darnell gay in an organ-specific, tissue-specific, or cell type—specific manner.

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